Biopharma · FDA Approvals · Stock
AN2 Therapeutics Inc is a biopharmaceutical company focused on discovering and developing novel small molecule therapeutics derived from its boron chemistry platform. The company has a pipeline of boron-based compounds in development for Chagas disease, non-tuberculous mycobacterial (NTM) and melioidosis, along with ea…
Assets on file: boron-based LeuRS inhibitors, epetraborole
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AN2 Therapeutics to Present Phase 2 Epetraborole Design in PV at MPN Congress
AN2 Therapeutics will present the design of its planned Phase 2 trial of oral epetraborole for phlebotomy-dependent polycythemia vera at the 18th International Congress on Myeloproliferative Neoplasms on October 29, 2026. This is a poster presentation (number 148) detailing the study in patients with PV.
AN2 Therapeutics Extends Gates Foundation Funding for GSK TB LeuRS Collaboration
The Gates Foundation extended funding to AN2 Therapeutics to support its ongoing research collaboration with GSK on boron-based LeuRS inhibitors for tuberculosis. This builds on prior work validating LeuRS as a target (shared with epetraborole and ganfeborole). No new clinical milestones, regulatory filings, or trial data are disclosed.
AN2 Therapeutics to start Phase 2 epetraborole PV trial 3Q26
AN2 expands oral epetraborole development into a Phase 2 proof-of-concept study in phlebotomy-dependent polycythemia vera (PV). The trial is expected to begin in India in 3Q26, with initial data readouts possible as early as 4Q26 and continuing through 2027.
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